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Have you ever wondered what the difference is between the brand name veterinary products your veterinarian sells and the products in catalogues and tack stores that claim to be exactly the same but cheaper and without a prescription? Most people think of these as generics, over the counter versions of these medications much like we have generic and OTC versions of our human products like allergy medications and painkillers. But this is may not be true and the distinction between prescription, generic and a compounded drug is very important to understand. A brand named prescription medication is one that is FDA approved and comes with all the bells and whistles of a newly developed product. Once this new product’s patent expires, other companies can produce the same drug, using the same formula, same dosage, same ingredients and same form, but usually at a lower cost. Generic medications go through the same rigorous FDA approval process to assure efficacy and safety before they are on allowed on the shelves.

To “compound” a medication is to mix drugs to create a product that is not commercially available (most common in vet med) or to change the delivery (pill to liquid) or flavor (most common in pediatric med). Compounding pharmacies are mostly self-regulated and have little to no external oversight, meaning no one is making sure their products contain what the label claims. This is different from a “generic” medication, which has FDA approval and regulations.

Prescribing generic forms of medications is completely legal because the FDA has approved these products. In veterinary medicine the FDA only allows for compounding of drugs that are not commercially available in an FDA approved form. Prescribing and using a compounded drug that is commercially available, besides being against the law, may not give you the results you are looking for, or worse, can be dangerous.

An FDA study showed that 34% of compounded drugs do not meet the potency standards compared to their approved counterparts, and most of these had less than 70% of the active ingredient the label claimed!!!  Another recent study presented at last year’s AAEP Convention compared compounded omeprazole products (lower cost versions of Gastrogard for the treatment of ulcers). The compounded forms had less than 63% of the label claim of omeprazole. Meaning, you’d have to give almost two tubes of compounded omeprazole to get the same effect as a single tube of Gastrogard! Additionally the materials used to make these medications do not always come from high quality sources or FDA approved manufacturers making their safety and stability questionable as well.

One of the most common examples of proper compounding in veterinary medicine is pergolide, the medication used to treat Cushing’s Disease in horses. Years ago there was an FDA approved human formulation of the drug that we were able to give to our horses. But more recently they had stopped making this medication for humans and we were forced to use a compounded form to continue treatment on these Cushing’s cases. Because these were not regulated formulations there was always a question as to whether or not there was the right amount of drug in the compound. Was the horse not responding because the diagnosis was wrong or the condition was worsening? Or was it just that we wanted to give 1mg of drug per day but the formulation only contained 0.5mg? Often times finding the right dose for each horse was a guessing game. Thankfully a new FDA-approved equine formulation of pergolide is on the market- Prascend® (Boehringer Ingelheim). Though many people have become used to using the compounded powder or suspension, veterinarians will be switching over to the approved product because we can be confident that it is efficacious and safe for our patients.

While we will always need to compound some drugs in order to have the full arsenal available to keep our animals healthy, when we do compound, we closely research the company and often employ outside labs to verify the concentration and purity.  So talk to your veterinarian about compounded medications and beware of online companies offering compounded versions of medications at reduced prices (especially if it is a prescription med and they do not ask for a script!) because you may not be getting what you need!

 
 
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Last post we talked about my horrible eating habits as a child and my misconceptions on how to formulate an equine nutrition protocol. Remember hay is not just a side salad, it is the basis of a diet, and grain is not a meal, just a multivitamin. So with that in mind let’s think about how we should adjust the horse’s diet to alter the number of calories being fed. First we have to do some math. Let’s say your dressage horse was burns ~23,000 calories per day. To get all of those calories into him, you gave 14,990 calories a day in hay and an additional 8,010 calories a day in the form of a complete performance feed. This is a diet that meets your calories requirements and is balanced and complete in vitamins and minerals.

Now imagine what will happen when your horse enters retirement and trades in his days of half-passes and piaffe for light hacks and trail rides. Because of his decreased activity he is now only burning 16,500 calories per day. If you continue to feed his old diet he will surely get fat! So what do you do? How do you decrease the amount of calories while maintaining a complete and balanced diet?

Most people will say, “Just cut back on his grain.” This is both good and bad advice. It is good that most people recognize that if we are going to alter anything we should alter the grain and leave the hay (the uber important fiber source) alone. The bad thing about just cutting back on the amount grain is you’re not just cutting calories.

This brings us back to the multivitamin analogy. Let’s say you take a multivitamin that for some reason contains 1000 calories but you are looking to loose a little weight by cutting back on your calorie intake (and exercising, right?). If you cut that multivitamin in half you will save yourself 3500 calories a week, that’s enough to lose a whole pound! Great right? Wrong, because by cutting that multivitamin in half, you may be halving your calories but you are also halving the amount of vitamins and minerals you are ingesting…not ideal.

That’s the same thing we do to our horses by just cutting back on the amount of the same old grain. You can’t keep giving him the same amount of grain because of the calories but you want to make sure you are providing the right levels of the essential vitamins and minerals. And if you feed a 1,000 pound horse half of the recommended amount of feed (the amount of complete performance feed intended for a 500 pound horse) you will be giving half the calories, sure, but also be giving half the nutrients. So what can we do? Well what would you do if it were you and the 1,000-calorie vitamin? You’d get a new vitamin! Right?!?

And that’s exactly what we should do for our horses, don’t just give a smaller amount of the same grain, get a different grain, one that has a more appropriate level of calories for your horse’s needs. There are so many good product lines on the market that contain multiple options for a complete balanced feed for horses at different activity levels. Pick one that’s right for your horse. Find a feed that will only provide 1,500 calories but still 100% of the recommended vitamins and minerals. Reed the feeding recommendations, they tell you what class of horse the feed is intended for: Maintenance (the lawn art), Light Work, Heavy Work, Pregnant/Lactating. Make sure you are always providing a complete balanced diet to your horse; regardless of how many calories he needs to keep his waistline in check and keep him eating out of your hands.
 

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